The sour cherry’s seed kernel contains vegetable oils including unsaturated fatty acids, oleic acids, α-tocopherol, tocotrienols, and tocopherol-like components. Previous studies have measured the total anthocyanins, total phenolic content, and Trolox equivalent antioxidant capacity in the sour cherry juice. The chemical, biological, functional, and technological properties of the sour cherry pomace and sour cherry seeds have already been described. Preparation of Seeds Powder and Juice from Tart Cherries Several techniques were performed to determine the possible protective effect of tart cherry supplementation against liver steatosis induced by obesity.Ģ.2. This study evaluates in DIO rats and the effects of the juice and seed powder of Prunus cerasus L., monitoring them for 17 weeks compared to age-matched control rats, fed with a standard diet (CHOW rats). These compounds, cyanidin-3-glucosyl-utinoside, cyanidin-3-rutinoside, cyanidin-3-glucoside, and their a glycone, cyanidin, have exhibited in vitro antioxidant and cyclooxygenase inhibitory activities. The current animal research suggests that tart cherry ( Prunus cerasus L.) confers health benefits because it is an excellent source of anthocyanins. Plenty of evidence suggests that anthocyanin-rich plant extracts modify lipid metabolism in vitro and reduce hyperlipidemia in vivo. Anthocyanin is considered one of the flavonoids with a positive charge at the oxygen atom of the C-ring, which is a flavonoid basic structure. For instance, anthocyanins are phytochemical flavonoids found in red-, blue-, and purple-pigmented fruits and vegetables. Thus, they have been proposed as possible therapeutic tools for several diseases. Indeed, natural bioactive compounds maintain low levels of reactive oxygen intermediates and inhibit the prostaglandin synthesis. Many compounds present in fruit and vegetables have important nutraceutical properties, such as antioxidant and anti-inflammatory components. Therefore, the availability of useful animal models reflecting human obesity, such as diet-induced obese (DIO) rats, is crucial in the exploration of innovative compounds for the pharmacological treatment of obesity. ![]() A high-fat diet (HFD) represents the etiology of obesity in modern societies. Increased food intake, reduced physical activity, and altered metabolic processes affect energy balance, inducing obesity. The prevalence of obesity has reached epidemic proportions. Moreover, it is characterized by inflammation that alters cell metabolism and insulin signaling in metabolically active tissues. Obesity consists in the abnormal deposition of adipose tissue, associated with metabolic and chronic diseases, such as type-2 diabetes, heart diseases, hypertension, non-alcoholic fatty liver disease (NAFLD), and cancer. This study suggests that tart cherry supplementation, although it did not reduce body weight in the DIO rats, prevented its related risk factors and liver steatosis. Interestingly, tart cherry supplementation enhanced both unfolded protein response (UPR) and autophagy. In the liver of the DIO compared with rats fed with a standard diet (CHOW), a down-regulation of the GRP94 protein expression and a reduction of LC3- II/LC3-I ratio were found, indicating endoplasmic reticulum stress and impaired autophagy flux. Indeed, sections of the DIO rats presented hepatic injury characterized by steatosis, which was lower in the supplemented groups. In the DJS rats, computed tomography revealed a decrease in the spleen-to-liver attenuation ratio. In the DS and DJS groups, there was a decrease of systolic blood pressure, glycaemia, triglycerides, and thiobarbituric reactive substances in the serum. After 17 weeks, the DIO rats showed an increase of body weight, glycaemia, insulin, and systolic blood pressure. DIO rats were exposed to a high-fat diet with the supplementation of tart cherry seeds powder (DS) and seed powder plus juice (DJS). This study evaluated the effects of anthocyanin-rich tart cherries in diet-induced obese (DIO) rats. ![]() The fruits-intake, containing phytochemicals, is inversely correlated with their development. The accumulation of adipose tissue increases the risk of several diseases.
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